Essentially, a hinge is held open by a water-soluble lock. His attempts to make a joint that changes when submerged in the water looked at several options: material that can absorb water, material that expands with temperature, and - the selected option - a dissolvable locking mechanism. has been reading about this technology and decided to try to replicate it using his conventional 3D printer. That’s happening at the Wake Forest Institute for Regenerative Medicine, where in February researchers 3D-printed structures made of living cells that could replace human tissue.īefore 4D printing goes mainstream, researchers must refine their ability to precisely control responses and develop standards, performance certifications and regulatory policies, says Vinod Baya, director of PwC’s Center for Technology and Innovation.Įven so, Baya acknowledges that the emerging ability to program specific responses is a game changer: “It’s like giving nonliving matter the characteristics of living matter.A 4D printed object is like a 3D printed object, but it changes shape or self-assembles when its environment changes. The newest frontier of 4D printing is growing tissues and organs in a laboratory setting. During a TED Talk, Tibbits described smart material that can self-assemble and even “think” if scientists embed that ability in its DNA. Their collaboration resulted in the first 4D-printed objects capable of self-adapting shapes that can change form. Similar research is under way at the Massachusetts Institute of Technology’s Self-Assembly Lab, led by Skylar Tibbits, who, along with researchers at Autodesk and Stratasys, spearheaded the 4D printing process. Researchers place tiny cellulose on a flat print bed with enough room to expand and immerse them in water, which allows scientists to control how the shape evolves. The printed ink is a hydrogel embedded with stiff cellulose fibrils. “By changing the print path, we were able to create a variety of shape-changing architectures,” Gladman says. Professor Lewis’s lab set up its 3D printer to use an extrusion-based printing process, using G-code programming to print architectures in about 10 minutes.

“We have already demonstrated the reversibility of this system with temperature by incorporating a thermally reversible monomer,” Gladman says. Researchers also will study materials with biocompatibility or electrical conductivity. Next steps include working on a suite of inks that are capable of responsive, reversible shape change and are able to react to stimulants such as heat, light and pH level. At this stage, immersion in water is the best medium because biomedical and tissue engineering applications also use hydration. Their latest project involves printing transformable tissue engineering scaffolds that can support cell growth. The Harvard team’s method allowed them to align cellulose fibrils in the ink, Gladman says. Previous researchers achieved simple shape changes using multiple materials or induced movement through magnetic field forces. Lewis of Harvard University’s Wyss Institute for Biologically Inspired Engineering. Sydney Gladman, a research assistant who works with Hansjörg Wyss Professor Jennifer A.

The choice of hygroscopic ink was critical to the study’s success, says A. The resulting shapes, modeled after flowers, mimic the movement of leaves and petals as they react to stimuli. Harvard University researchers recently used hygroscopic ink, which absorbs water, to push 3D printing into the 4D realm. Scientists are borrowing from nature to print objects that can move independently when submerged in water.

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